NFL 2025/26: 49ers – Panthers Prediction, Stats & Odds
Purdy is finally back at San Francisco and with him 41 points were conjured up on the tableau last week – the Californians’ offense has not been so productive since 2023.
Precisely because the NFL schedule smiles at the sun-drenched home side and the opponent is not at 100 percent, I take exactly this betting path in my 49ers Panthers tip!
I will fall back on one or the other Oddset odds boost, which is also freely accessible to you!
Carolina has big problems successfully converting 3rd down attempts and will be put under a lot of pressure by the San Francisco defense at Levi’s Stadium. Even if they have to do without Nick Bosa and Fred Warner due to injury!
49ers vs. Panthers Predictions:
San Francisco: Over 35.5 points at odds around 3.70 sounds exaggerated in your eyes? In my opinion, our 49ers Panthers AI forecast has rather correctly recognized the signs of the times!
Unimaginable just a few weeks ago, but the return of Purdy at the QB position is a game changer that has breathed new life into the offense right away – and how!
“Mr. Irrelevant” conjured up a picture-perfect passer rate of 133.5 against Arizona and could again successfully make almost every pass attempt against a sometimes lax secondary like that of the Panthers.
Christian McCaffrey with rushing TD at odds around 1.50 on the Betano app is a bet that is worth it again. Because with a functioning passing game under Purdy, possibly the best running back of last season will come into his own much better from now on!
McCaffrey has already scored +2 touchdowns in three of the 49ers’ last four games against NFC teams.
The last AI suggestion, Win both halves of the game: 49ers, leads to a payout of about 2.65 if successful and also has first-class chances of success in my eyes. I certainly won’t be asked twice!
What you need to know about 49ers vs. Panthers betting
- Christian McCaffrey has scored two or more touchdowns in three of the 49ers’ last four games against NFC opponents.
- George Kittle recorded at least 61 receiving yards in each of his last seven regular-season appearances for the 49ers as the home favorite against NFC opponents.
- The Panthers lost each of their last eleven games after an away win.
- The 49ers have won each of their last five home games against NFC South opponents.
- Brock Purdy recorded at least 11 rushing yards in 12 of his last 13 appearances in California.
