NFL 2025/26: Colts – 49ers Prediction, Stats & Odds
While the Oddset odds boost is suitable for any time of the year, I would be careful not to base my own Colts 49ers tip on data and facts alone.
Because yes, San Francisco hasn’t looked good at all this season against teams with a positive record – and Indy is just such a team.
But while a few weeks ago I would have attached a lot of importance to this statistic, I would now deliberately ignore it just before Christmas.
Because the Colts are in free fall – four defeats in a row clearly show how big the crisis is.
Colts vs. 49ers Predictions:
Our data model has confronted me with one or the other Colts 49ers tip, which I am quite willing to pay attention to.
By the way, you should also have the promising suggestion “49ers over 2.5 touchdowns” for odds around 1.50 on your screen.
San Francisco is on the rise – 4 wins in a row. In addition, Brock Purdy usually turns up the heat regularly at this late time of year: In 4 of his last 5 December games, he came to over 295 passing yards each.
“2+ Touchdowns: Christian McCaffrey” promises you values around 2.92 in view of the current Colts 49ers odds of most bookmakers.
This player bet is promising for me because the running back should be sent into the fray by his head coach again and again against the yielding Colts run defense.
I also like “Jauan Jennings with receiving TD” as a suggestion at odds around 2.42. Because the 49ers player has already collected over 24 receiving yards in 8 of his last 9 appearances against AFC teams and should not miss out this time either.
What you need to know about Colts vs. 49ers betting
- Brian Robinson reached at least 24 rushing yards in nine of his last ten December games.
- Brock Purdy recorded at least 295 passing yards in four of the 49ers’ last five December games.
- The 49ers have won each of their last six games against AFC opponents who were on a losing streak.
- Brock Purdy recorded at least 23 complete passes (completions) in each of the 49ers’ last three December games.
