Napoli – Pisa Tip, AI Prediction & Odds 09/22/2025

Napoli – Pisa Prediction Serie A, Matchday 4 on Monday, 09/22/25 at 8:45 p.m.

When you find yourself in a duel with the massive Erling Haaland, you have to pull out a damn long scythe to touch the ball and not the Norwegian when sliding in.

SSC captain Di Lorenzo will now have learned this lesson, leaving his team a man down after committing a last-ditch tackle. The subsequent goals conceded were a logical consequence of this action.

However, my Napoli vs. Pisa prediction for Monday night’s Italian game, posted on Merkur Bets Germany, remains unaffected: a win for the Neapolitans without conceding a goal.

This is because the Azzurri are a very consistent team when it comes to Serie A home games. After all, they haven’t lost at the Stadio Diego Armando Maradona in 12 league games and have even kept a clean sheet in half of those games.

Napoli vs. Pisa AI predictions:

Right from the start, our Napoli Pisa AI prediction suggested that the hosts would win and that there would be fewer than three goals.

I quickly thought of the perfect bet offer in the Bwin app: Napoli to win 1-0, 2-0, or 3-0, which promises a 2.2x win multiplier and can be found under the category “Exact score (multiple options)”.

Predicted chance of winning:

Napoli win
Draw
Pisa win
74.1%
18.1%
7.9%

1. Goalscorer: Kevin De Bruyne is almost a digital stroke of genius at average Napoli Pisa odds of 7.50. The Belgian has already scored in two of his first three Serie A appearances for SSC and is also well rested.

For tactical reasons, the Belgian was recently substituted after just 20 minutes to make way for a defender.

I would also select under 3.5 goals at around 1.40 in a comprehensive betting app if I were generally skeptical about a Neapolitan victory. Either way, there should be very few goals scored on Monday evening.

What you need to consider when betting on Napoli vs. Pisa

  • Napoli are unbeaten in 12 Serie A home games (9W, 3D) and have kept six clean sheets in that run.
  • Napoli have scored the first goal in 15 of their last 20 home league games.
  • Only one of Pisa’s last five away games has seen more than 2.5 goals scored.
  • Pisa is the only Serie A team that has not scored a goal after halftime.

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