My Seahawks 49ers prediction: SEA win & Over 40.5
These are the arguments for my betting tip:
- 49ers: Lost 12 of their last 13 Sunday games at Lumen Field.
- Seattle won the last matchup between these two teams 20-17.
- Seahawks: Won last 3 games as underdogs against NFC West.
NFL 2025/26: Seahawks – 49ers Prediction, Stats & Odds
When the Seahawks and 49ers take to the field together on Sunday, it’s clear that the battle for the NFC West lead will be decided early on.
San Francisco is back after a disappointing season and still has a strong lineup with George Kittle, Christian McCaffrey, and Brock Purdy – only the departure of Deebo Samuel Sr. is a huge blow to the fans, of course!
Now would be the perfect time to register with bet-at-home! That way, you can put my Seahawks vs. 49ers prediction to the test and, with a little luck, be among the winners of this first week of the NFL season!
Seahawks vs. 49ers predictions:
Our AI model predicts a home win in its very own Seahawks 49ers AI prediction – and not without reason!
The “Legion of Boom” beat none other than the Kansas City Chiefs 33-16 in the preseason and also won their last showdown with San Francisco.
The odds offered in this context, which on average will double your stake, are also impressive.
Kenneth Walker III scoring a TD at odds of around 2.00 also appeals to me. Seattle often moves the ball on the ground, and the running back was one of the surprises of last season.
Over 43.5 points at odds of around 1.83 is worth considering, even without an odds boost. That’s because each of the 49ers’ last six away games against an NFC West opponent exceeded the points total set by German betting providers in advance.
What you need to consider when betting on Seahawks vs. 49ers
- The visiting team has won 12 of the Seahawks’ last 13 games.
- The last 6 49ers away games against NFC West opponents have each exceeded the points line.
- 7 of the last 8 Seahawks home openers against NFC teams have gone under the point spread.
- The 49ers have scored the first touchdown of the game in each of their last 7 matchups with the Seahawks.
