NFL 2025/26: Seahawks – 49ers Prediction, Stats & Odds

I spent more time scouring the offerings of old and new sportsbooks for suitable offers and great odds boosts than with my Seahawks 49ers tip itself.
For me, it was clear early on that the “Legion of Boom” would prevail relatively clearly. Even if I don’t want to take anything away from San Francisco’s amazing victory over the defending champion from Philly the previous week.
But just as Superman can’t stand Kryptonite, Brock Purdy hates being subjected to massive pressure immediately after the snap. And if there’s one thing the Seattle defense has rehearsed well, it’s definitely their own blitz.
Seahawks vs. 49ers Predictions:
San Francisco won the first battle of the season 17-13, but the 49ers lost the second match with Seattle in Week 18 3-13 – and that’s the only thing that counts!
Incidentally, the decisive factor for the success of the “Legion of Boom” shortly before the start of the playoffs was the significant increase in its own lightning rate, with which it was able to massively affect Brock Purdy.
Consequently, the Seahawks 49ers AI prediction based on this is as follows – San Francisco: Under 16.5 points at odds around 2.30. Because our data model is quite rightly confident that Seattle will maintain this battle-tested gameplan on Sunday.
At odds of around 1.88, less than 44.5 points corresponds to what the bookmakers call the so-called “under”. And it is precisely this selection that would be ideally suited in this match to land on your own betting slip.
The respective defensive performance will determine the winner – according to the motto: Offense wins games, Defense wins championships!
I therefore expect only a few points, but I would not completely disregard the player bet Zach Charbonnet with TD, even at odds around 1.78.
After all, the Seahawks running back has scored a six-pointer in each of his last three games – including against the upcoming opponent! He is usually their go-to guy when SEA wants to conjure up points on the tableau himself!
What you need to know about Seahawks vs. 49ers betting
- Zach Charbonnet has scored a touchdown in each of his last 3 games (4 total)
- San Francisco have won 7 of their last 9 head-to-head meetings
- When fired, Purdy has thrown 7 touchdowns and 4 interceptions!
- Under 37.5 points in the last three meetings between SEA and 49ers



